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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Mycophenolic acid (MPA) is a potent, selective, uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) which inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA.”
“Mean ± SD apparent half-life and plasma clearance of MPA are 17.9 ± 6.5 hours and 193 ± 48 mL/min respectively following oral administration and 16.6 ± 5.8 hours and 177 ± 31 mL/min respectively following intravenous administration.”
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“MPA is metabolised principally by glucuronyl transferases ((predominantly isoform UGT1A9)) to form the pharmacologically inactive phenolic glucuronide of MPA (MPAG).”